Abstract
Various epidemiological studies have shown an inverse association between the consumption of polyphenols or polyphenol-rich foods and the risk of neurodegenerative, hepatic diseases. The research aimed to fight oxidative stress and lipid metabolism changes in the context of administration of antioxidants, such as polyphenolic extract of Aronia melanocarpa and zinc aspartate, known for its neurotrophic effects in intrinsic aging processes. Zinc aspartate and poly-phenolic extract from Aronia melanocarpa reduce oxidative stress values both in serum, liver homogenate, and in brain homogenate. Oxidative stress assessed by malondialdehyde (MDA), glutathione peroxidase (GPx) and total antioxidant capacity (TAC) markers was reduced in animals receiving additional zinc salts and polyphenolic extract of Aronia melanocarpa, which underlines their role in antioxidant defense. This combination produces more superior hypolipidemic and antioxidant effects than in the case of separate administration within experimental senescence induced in the murine model. Further studies will investigate the effect of different dose combinations of zinc aspartate and polyphenolic extract of Aronia melanocarpa at different periods of treatments on age-associated liver/cerebral dysfunction.
Highlights
Identification of senescence and neurodegenerative diseases markers or susceptibility for their existence, carried out in order to implement actions targeted at prevention has been a priority for medical research
The experimental study fulfils all the requirements of the guide regarding the use of laboratory animals and biological preparations issued by the International Society of Pain Study (IASP) and the European Council Committee (86/609/EEC)
Oxidative stress assessed by MDA, glutathione peroxidase (GPx) and total antioxidant capacity (TAC) markers was reduced in animals receiving additional Zn salts and polyphenolic extract of Aronia melanocarpa, which underlines their role in antioxidant defense
Summary
Identification of senescence and neurodegenerative diseases markers or susceptibility for their existence, carried out in order to implement actions targeted at prevention has been a priority for medical research. The turnover of zinc (Zn) in the brain is slower than that in the liver and in other peripheral tissues, and this is due to the presence of blood-brain barrier. This system of barriers is important for Zn homeostasis in the brain and its alteration may be associated with brain dysfunctions and neurological diseases [5] [6]. It is important to describe the possible role of nutritional supplementation with fruits containing large amounts of polyphenols, such as anthocyanins, in reversing or forestalling senescence deficits
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