Abstract
Four new bis-imidazolium salts 3–6 and their di- and polynuclear silver(I)–N-heterocyclic carbene (Ag(I)–NHC) complexes 7–10 were synthesized and characterized by using various analytical techniques. Single-crystal studies of 8 revealed a dinuclear structure whereas that of 9 revealed an interesting polynuclear structure. The quasi-reversibility of redox events in electrochemical study of 9 indicated that reduction produces unstable decomposed species and oxidation may be ascribed to these decomposed species. All the compounds were studied for their in vitro anticancer study against human breast cancer (MDA-MB-231) and colon cancer (HCT-116) cells. The study revealed that Ag(I)–NHC complexes are comparatively more potent than NHC precursors (salts). MDA-MB-231 cells appeared more sensitive to complexes than HCT-116 cells while reverse is the case for NHC salts.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
