POLYMORPHOUS ADENOCARCINOMAS WITH CLINICAL PRESENTATION SHOWING STIPPLED SURFACE

Abstract

Polymorphous adenocarcinoma (PAC) is a rare malignant neoplasm that primarily originates from minor salivary glands. Surface changes with a rough or stippled overlying mucosa in clinical presentation of PAC have been reported. We present 2 cases of PAC in middle-aged female patients with clinical presentation showing a stippled surface. The lesions were slow-growing asymptomatic masses located in the hard palate exhibiting a stippled surface mucosa. Incisional biopsy was performed, and histological examination showed tumor infiltration of the superficial lamina propria with neoplastic cells arranged in single layer tubules, cribriform structures, and solid nests. Immunohistochemical examination showed positivity for S100, CK7, and p63. The Ki-67 index was <1%. The diagnosis was PAC, and the patients were referred to an oncologic hospital. The overlying mucosa in PAC could show clinical features of a rough or stippled surface, which might help to differentiate minor salivary gland neoplasms.