Abstract
The objective of this study was to examine the allelic and genotypic profiles of four SNPs of bovine Toll-Like receptor 1 (TLR1), Toll-Like Receptor 4 (TLR4) and Solute Linkete Carier 11A1 (SLC11A1) genes in Holstein, two Turkish native breeds and their crossbreds in Turkey. For this purpose, a total of 1023 cattle from Holstein (HL, n= 410), Anatolian Black (AB, n= 106), East Anatolian Red (EAR, n= 84), Anatolian Black Crossbreed (ABC, n= 124) and East Anatolian Red crossbreed (EARC, n= 299) breeds were examined for four SNPs. Samples were genotyped using by the PCR-RFLP method. According to the TLR1 (+1380) SNP, EAR was in Hardy-Weinberg equilibrium (HWE) while the AB, HL and native crossbreeds were deviated from HWE. All cattle breeds were in HWE for the TLR1 (+1596) SNP. In terms of TLR4 (+10) SNP, the CC genotype had the highest frequency in HL and native crossbreeds whereas the AB and EAR breeds were monomorphic and only CC genotype was found these breeds. According to the SLC11A1 (+1066) SNP, the CC genotype had the highest while the GG genotype frequency the lowest in all breeds. In addition EAR breed was in HWE while the AB, HL and native crossbreeds deviated from HWE.
Highlights
The immunity is divided into two namely the innate and adaptive immunity, in mammals
Polymorphisms of Toll-Like receptor 1 (TLR1), Toll-Like Receptor 4 (TLR4) and Solute Linkete Carier 11A1 (SLC11A1) Genes in Some Cattle Breeds Reared in Turkey, Arslan et al
TLR1/TLR2 heterodimers and TLR4 recognise mycobacterium Pathogen-Associated Molecular Patterns (PAMPs), macrophages and dendritic cells are activated for immune response (Brightbill et al 1999; Chang et al 2006; Hawn et al 2007)
Summary
The immunity is divided into two namely the innate and adaptive immunity, in mammals. The resulting TLR1/TLR2 complex recognises different bacterial cell wall ingredients such as lipoproteins and lipopolysaccharides, mediating a natural immune response against Gram-positive and Gram-negative bacteria species (BuwittBeckmann et al 2006; Russell et al 2012). In this way, Polymorphisms of TLR1, TLR4 and SLC11A1 Genes in Some Cattle Breeds Reared in Turkey, Arslan et al TLR1/TLR2 heterodimers and TLR4 recognise mycobacterium Pathogen-Associated Molecular Patterns (PAMPs), macrophages and dendritic cells are activated for immune response (Brightbill et al 1999; Chang et al 2006; Hawn et al 2007). The TLR4 gene was reported to be a strong candidate gene for disease resistancy, such as against mastitis (Ogorevc et al 2009), paratuberculosis (Mucha et al 2009), and brucellosis (Prakash et al 2014)
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