Polymorphisms of the vitamin D receptor gene (FOKI, CDX2, and GATA) and susceptibility to chronic periodontitis in diabetic and non-diabetic individuals: A case-control study.

Abstract

The aim of the present study was to evaluate the distribution of single-nucleotide polymorphisms (SNP) (variants FOKI [rs2228570], CDX2 [rs47908762], and GATA [rs4516035]) in the vitamin D receptor in individuals with type 2 diabetes mellitus and chronic periodontitis (DM2+CP), CP alone, and healthy individuals, and to investigate the relationship with susceptibility to CP. In total, 280 individuals (116 with DM2+CP, 95 with CP alone, and 69 healthy individuals) were genotyped using real-time polymerase chain reaction with allele-specific probes. Significant differences (P<.05) were found among the groups with regard to socio-epidemiological variables (sex, marital status, income, smoking habit, and schooling) and clinical-epidemiological variables (age, number of teeth, probing depth, clinical attachment loss, gingival bleeding index, and visible plaque index). The C allele was significantly more frequent among the healthy individuals (34.8%) than those with DM2+CP (23.5%) (odds ratio [OR]=.58, 95% confidence interval [CI]: . 35-.94, P=.022). Likewise, the CC allele was significantly more frequent among healthy individuals (11.6%) than those with DM2+CP (2.6%) (OR=.17, 95% CI: .03-.79, P=.015). The results suggest that the presence of these variants could lead to a lower susceptibility to DM2 and CP. No other significant differences among groups were found for the other SNP investigated.