Abstract
Purpose Because sex hormones are involved in the development of benign prostatic hyperplasia (BPH), we examined associations between polymorphisms in genes involved in androgen and estrogen metabolism and measures of BPH. Methods A cohort of 510 community-dwelling Caucasian men (median age 60 years in 2000), randomly selected from the Olmsted County, MN population, participated in a longitudinal study of BPH. From 1990 through 2000, urologic measures of BPH were assessed biennially, including lower urinary tract symptom severity, peak urinary flow rates, prostate volume, and serum prostate specific antigen (PSA) level. Acute urinary retention and treatment for BPH were assessed from community medical records. Men were genotyped for candidate genes involved in androgen and estrogen metabolism. Results With the wildtype genotype as reference, significant associations (p Conclusion These findings suggest possible associations between HSD3B1, CYP19, and ARE1 gene polymorphisms and measures of BPH. While no one polymorphism is associated uniformly across surrogate measures of BPH, these data suggest that further examination of these genes for their potential role in the etiology, diagnosis, prevention, or treatment of BPH may be warranted.
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