Abstract
The Journal is the primary organ of Continuing Paediatric Medical Education in Sri Lanka. The journal also has a website. Free full text access is available for all readers.The Sri Lanka Journal of Child Health is now indexed in SciVerse Scopus (Source Record ID 19900193609), Index Medicus for South-East Asia Region (IMSEAR), CABI (Centre for Agriculture and Bioscience International Global Health Database), DOAJ and is available in Google, as well as Google Scholar.The policies of the journal are modelled on the Committee on Publication Ethics (COPE) Guidelines on Principles of Transparency and Best Practice in Scholarly Publishing. Sri Lanka Journal of Child Health is recognised by the International Committee of Medical Journal Editors (ICMJE) as a publication following the ICMJE Recommendations.
Highlights
The genetic factors of the host can influence the response to HIV infection
There was no significant relationship between sex (p=0.059), duration of therapy 1Department of Child Health, Faculty of Medicine, 2Department of Parasitology, Universitas Airlangga/Dr Soetomo Hospital Surabaya, Indonesia *Correspondence: dominicushusada@yahoo.com https://orcid.org/ 0000-0001-9191-9546 (Received on 28 July 2020: Accepted after revision on 18 September 2020) The authors declare that there are no conflicts of interest Personal funding was used for the project
Polymorphism of the Apolipoprotein C3 (APOC3) gene is associated with decreasing high density lipoprotein (HDL) and non-HDL in adult patients, and affect the total cholesterol levels in children
Summary
Genetic polymorphisms related to HIV infection influence lipid metabolism[1]. Polymorphism of the Apolipoprotein C3 (APOC3) gene is associated with decreasing high density lipoprotein (HDL) and non-HDL in adult patients, and affect the total cholesterol levels in children. The presence of metabolic disorders is associated with high levels of lipids in the blood associated with hypersensitivity reactions to drugs so that it can lead to therapeutic failure from anti-retroviral therapy (ART)[2]. Genetic determination with APOC3 has a large impact in the selection of therapeutic regimens and predicts the side effects of highly active antiretroviral therapy (HAART) drugs[2]. Genetic factors can affect the therapeutic response to HIV infection. Apolipoprotein C3 (APOC3) polymorphism is related to metabolic disorders and hypersensitivities and affect tolerability that impacts adherence to highly active antiretroviral therapy (HAART).
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