Abstract
Objective: to evaluate alleles distribution of single nucleotide polymorphism 118A>G of μ1-opioid receptor (OPRM1) gene in patients with renal neoplasm and benign diseases.Materials and methods. 100 consecutive patients after renal surgeries retrospectively divided into groups with neoplasm (n = 29) and benign diseases (n = 71).Results. The incidence of renal neoplasm was much higher in homozygous 118A patients than in AG + GG group (36.4 % vs. 14.7 %; p = 0.035).Conclusion. Single nucleotide polymorphism 118A>G OPRM1 gene may be of value in genesis of renal neoplasm.
Highlights
Polymorphism of μ1-opioid receptor (OPRM1) gene may be of value in genesis of renal malignant neoplasm A.L
Materials and methods. 100 consecutive patients after renal surgeries retrospectively divided into groups with neoplasm (n = 29) and benign diseases (n = 71)
Single nucleotide polymorphism 118A>G OPRM1 gene may be of value in genesis of renal neoplasm
Summary
Polymorphism of μ1-opioid receptor (OPRM1) gene may be of value in genesis of renal malignant neoplasm A.L. Single nucleotide polymorphism 118A>G OPRM1 gene may be of value in genesis of renal neoplasm. For citation: Potapov A.L., Kaprin A.D., Ivanov S.A. et al Polymorphism of μ1-opioid receptor (OPRM1) gene may be of value in genesis of renal malignant neoplasm. Сообщается, что эта мутация может иметь прогностическое значение у пациентов с раком пищевода и молочной железы, хотя данные отдельных публикаций противоречивы [6,7,8,9].
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