Abstract
In this study we document how it was possible to resolve the septic complications of abdominal surgery, subjecting a patient severely allergic to intravenous antibiotics. We performed the hemoperfusion with polymyxin-B columns (PMX-DHP), guiding the therapy by assaying endotoxin activity and evaluating the clinical status of the patient after each session of PMX-DHP. The stabilization of hemodynamic and inflammatory frameworks were immediately observed after the PMX-DHP. The patient could be safely discharged five days after the discontinuation of the therapy. Our findings confirms data already published in literature concerning the effectiveness of PMX-DHP.
Highlights
In this case study we report the particular case of a patient found to be severely allergic to two different pairs of antibiotics and were forced to suspend double antibiotic therapy in course
In recent years particular attention has been paid to antibiotic treatment coupled with standard therapy and carried out by hemoperfusion over columns with polymyxin-B, effective in neutralizing endotoxin originating from gramnegative bacteria [1]
No antibiotic therapy was performed during Polymyxin B-immobilized fiber hemoperfusion (PMX-DHP) treatment
Summary
In this case study we report the particular case of a patient found to be severely allergic to two different pairs of antibiotics and were forced to suspend double antibiotic therapy in course.In recent years particular attention has been paid to antibiotic treatment coupled with standard therapy and carried out by hemoperfusion over columns with polymyxin-B, effective in neutralizing endotoxin originating from gramnegative bacteria [1].Polymyxins have the unusual ability to bind to and neutralise endotoxin, this, rather than their antibacterial effects, might be of clinical value. We performed the hemoperfusion with polymyxin-B columns (PMX-DHP), guiding the therapy by assaying endotoxin activity and evaluating the clinical status of the patient after each session of PMX-DHP. In recent years particular attention has been paid to antibiotic treatment coupled with standard therapy and carried out by hemoperfusion over columns with polymyxin-B, effective in neutralizing endotoxin originating from gramnegative bacteria [1].
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