Polymeric Nanosuspension Loaded Oral Thin Films of Flurbiprofen: Design, Development and In Vitro Evaluation

Abstract

In the present investigation, effort has been made to stabilize optimized nanosuspension of flurbiprofen through oral thin film formulation. To overcome the issue of stability of nanosuspension and poor bioavailability of flurbiprofen, nanosuspension loaded oral thin films were developed by solvent casting method. Oral thin films can be prepared by simple and scalable method easily. Nanosuspension loaded oral thin films were evaluated for thickness, % moisture absorption and loss, surface pH, weight variation, folding endurance, drug content, disintegration time, in vitro drug release and stability. The resultant oral thin films depicted that the particles size range was retained even after their stability study for three months. The dissolution rate of all flurbiprofen oral thin films were significantly increased compared with its marketed oral formulation. Thus it can be concluded that, oral thin films have potential for stabilization of nanosuspension with improved drug release.