Abstract
The current investigation was aimed with the objective of formulating Selegiline fast dissolving oral thin films allowing fast reproducible drug dissolution in oral cavity thus bypassing the first pass metabolism to enhance the patient convenience and compliance in the effective treatment of Parkinson's disease. Oral thin films of Selegiline were prepared by solvent casting method with using different film forming agents like HPMC5LV, HPMC 15LV, HPMC50LV and HPMC K4M. Propylene glycol, Sucrose, Vanillin is used as a plasticizer, sweetening agent, flavouring agent respectively and citric acid as saliva stimulating agent. FDOFs were evaluated for physical characteristics, Surface pH, weight variation, thickness, folding endurance, percent drug content, percentage elongation, disintegration time, in vitro dissolution studies. Based on all the evaluation studies F18 is selected as optimized formulation and in vitro disintegration time and amount of drug release from the film was 9 seconds and 99.68% within 7 min respectively
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