POLYMERIC NANOPARTICLES BASED TOPICAL DELIVERY SYSTEMS IN PSORIASIS

Abstract

Psoriasis is a common inflammatory skin disease with an incompletely understood etiology. The disease is characterized by red, scaly and well-demarcated skin lesions. It is an immune – mediated chronic inflammatory skin disease affecting approximately 2-3% of worldwide population. Psoriasis has a negative impact on the patient’s health and quality of life and affects the quality of family members. Skin and joints affecting around 0.5-1% of children and 2-3% of adults. It can occur at any age, although the majority of cases develop before the age of 40 year and it is common in Children. Psoriasis is a chronic inflammatory disease, predominantly affecting the skin included in the group of immune mediated inflammatory disease and several systemic condition like metabolic syndrome, cardiovascular disease, diabetes, Arthritis, obesity, hypertension, Cancer are prevalent in psoriasis patients. This review offers inside into management of psoriasis and pharmaceutical approach for treatment for this disease. The review deals in details about topical drug delivery, phototherapy and biological against psoriasis. Review provides a detailed summary of the pathophysiology, epidemiology, of psoriasis. This review also summarizes different technology of nanotechnology methods of preparations.[26] Keywords: Psoriasis, skin disorder, inflammation, therapies for disease, Nanotechnology therapies.