Polymeric nano-hydroxyapatite coated with polylactic acid (PLA): considering new possibilities for radiopharmacy

Marta De Souza Albernaz,Alexandre Malta Rossi,Ralph Santos-Oliveira,Andre Linhares Rossi,Gilberto Weissmuller

doi:10.17229/jdit.2015-0210-012

Abstract

The use of nanotechnology - especially in the area of human health - is increasing every day, with the application of various materials such as hydroxyapatite being amongst the most studied. Consequently, the affinity of hydroxyapatite compatible with so many applications in the human body is evolving cutting edge technology - the result of which is nanoparticles. However, despite these important

Highlights

The design and development of a biomaterial that is able to replace the form and function of native tissue - whilst promoting regeneration without the onset of necrosis or scar formation - is a challenging area of research
We describe a successful method which uses polylactic acid as the polymer to encapsulate nano-hydroxyapatite: this culminates in new applications for oncology and radiopharmacy
The images obtained from using atomic force microscopy, show the formation of spherical structures with size ranging from 100 to 800 nm

Summary

Introduction

The design and development of a biomaterial that is able to replace the form and function of native tissue - whilst promoting regeneration without the onset of necrosis or scar formation - is a challenging area of research. Studies have indicated that nano-hydroxyapatite (n-HA) has excellent biological performance and remains a potential candidate to be used as a bioactive material for bone tissue repair [2]. The extensive application of n-HA is still limited because of its powder form and brittle nature. Biodegradable polymers and their co-polymers have been investigated widely and used for bone regeneration, dental repair, orthopedic fixation devices amongst other biomedical applications [3]

Materials and Methods

Results and Discussion

Conclusion