Abstract
Open letter to journal editors on: International Consensus Radiochemistry Nomenclature Guidelines
Highlights
Clarify the use of terms and rules concerning exclusively radiopharmaceutical terminology, i.e. nuclear- and radiochemical terms, symbols and expressions
* “non-isolated, estimated by radio-HPLC”, or, in the general experimental section: “All radiochemical yields were determined by HPLC of the crude product, unless stated otherwise.”, or alternatively use: ‘The radiochemical purity of the crude product was 67 %.”, or: “The radiochemical yield of “Y” determined from an aliquot of the reaction solution amounted to 67 %.”, or: “The radiochemical yield of crude “Y” was 67 % based on the amount of activity eluted from the HPLC column”
This term is useful, or necessary to indicate the efficiency of a labelling procedure
Summary
Unit of activity “Radioactivity” is a physical phenomenon, defined as the property of certain nuclei to spontaneously fragment or rearrange, resulting in the emission of radiation. “Activity” is the quantitative measure of radioactivity: The number of nuclear decays, occurring in a given quantity of material over a certain time interval, divided by that time interval. “Becquerel” (Bq) is the agreed SI derived unit for the quantity of activity. Molar activity is the measured activity per mole of compound; measured in Bq/mol (GBq/μmol). Specific activity is the measured activity per gram of compound; measured in Bq/g (GBq/μg). The instant of time of measurement must be stated; for example: “The molar activity was 50 GBq/μmol 2 h after the end of synthesis”
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