Polymeric complexes of synthetic polyelectrolytes and physiologically active component. Review

Abstract

In this paper research on polymeric complex of polyelectrolytes with enzymes and hormones is reviewed. A chromatographic method is discussed, for study of reversibly dissociating polymeric complexes, firstly for complexes that from rapidly under quasi-equilibrium conditions, where mass exchange takes place fairly rapidly, and for complexes that from relatively slowly. The methods proposed for calculation of the instability constants of the complexes and of the rate constants, are used for analysis of the state of complexes formed by interaction of synthetic polyelectrolytes with enzymes. Results of study of complex formation in relation to stabilization, activation and inhibition of physiologically active substances, are presented. Formation of complexes in solution is compared with their formarion from crosslinked polyelectrolytes (ion exchange resins) and physiologically active substances (enzymes and insulin).