Abstract
Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.
Highlights
Wound healing is dynamic and complex biological process that involves several consecutive healing phases [1]
The wound healing assessment of alginate-chitosan hydrogel sponges co-encapsulated with curcumin and honey demonstrated significantly accelerated wound closure of 94.14% in one week revealing them as potential wound dressings for pressure ulcers or diabetic foot [107]
The in vivo wound healing experiments using wounded diabetic Sprague Dawley rats showed that the wound areas covered with PCL/gum tragacanth nanofibers loaded with curcumin were completely closed on day 15 when compared to the control in which the wound area was reduced by 20.96% [119]
Summary
Wound healing is dynamic and complex biological process that involves several consecutive healing phases [1]. Biopolymers suffer from poor mechanical properties that can be overcome by combining them with synthetic polymers [11]. The synthetic polymers used in wound dressing formulations and antimicrobial properties. Itactivities has attracted the inflammatory, antibacterial and anti-oxidant activity [11] It has attracted the wide attention of many attention of many biomedical researchers, because of its biological effects, and because biomedical researchers, because of its biological but facts that because of itsthe excellent of its excellent biocompatibility and non-toxicity. These be overcome by by its poor water solubility and bioavailability These limitations can be overcome by loading curcumin into polymer-based materials. This review manuscript reports the in vitro and in vivo therapeutic outcomes of polymeric wound dressings loaded with curcumin.
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