Abstract
At present, there are various wound dressings that can protect the wound from further injury or isolate the external environment in wound treatment. Whereas, infection and slow self-healing still exist in wound healing process. Therefore, it is urgent to develop an ideal wound dressing with good biocompatibility and strong antibacterial activity to promote wound healing. Bacterial cellulose is a kind of promising biopolymer because it can control wound exudate and provide a moist environment for wound healing. However, the lack of antibacterial activity limits its application. In this paper, the advantages of bacterial cellulose as wound dressings were introduced, and the preparation and research progress of bacterial cellulose-based antibacterial composites in recent years were reviewed, including adding antibiotics, combining with inorganic antibacterial agents or organic antibacterial agents. Finally, the existing problems and future development direction of bacterial cellulose-based antibacterial wound dressings were discussed.
Highlights
Human skin covers the whole body surface, which is the barrier between human body and external environment, and plays an important role in preventing pathogens from entering human body (Byrd et al, 2018)
Wound repair is a physiological process affected by many factors, and its complexity often leads to some uncertainties, such as slow wound healing, secondary infection, and inflammation (Au-Crane et al, 2020)
The antibacterial activity of wound dressings plays an important role in anti-infection and promoting wound healing during wound treatment
Summary
Human skin covers the whole body surface, which is the barrier between human body and external environment, and plays an important role in preventing pathogens from entering human body (Byrd et al, 2018). Ye et al (2018) designed a new biocompatible sponge with excellent antibacterial properties by grafting amoxicillin onto regenerated bacterial cellulose (RBC), and the grafted RBC enhanced the antibacterial activity against fungi, Gram-negative and Grampositive bacteria, which had great potential in clinical application of wound dressings. The prepared TOBCP/Ag NPs composites have good biocompatibility and high antibacterial activity against E. coli and S. aureus to be a promising wound dressing.
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