Abstract
Total synthesis of the opioid tridecapeptide dynorphin (1–13) has been effected by solution acyl azide condensation of peptide segments corresponding to dynorphin (1–5) and dynorphin (6–13). The latter were prepared by stepwise high-load solid (gel) phase synthesis using a phenolic poly(acryloylmorpholine)-based support. The target peptide was deprotected by catalytic transfer hydrogenation.
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More From: International Journal of Biological Macromolecules
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