Polymer gel dosimetry for the TG-43 dosimetric characterization of a new 125I interstitial brachytherapy seed

Abstract

In this work, a polymer gel–magnetic resonance (MR) imaging method is employed for the dosimetric characterization of a new 125I low dose rate seed (IsoSeed® model I25.S17). Two vials filled with PABIG gel were prepared in-house and one new seed as well as one commercially available 125I seed of similar dose rate and well-known dosimetric parameters (IsoSeed® model I25.S06) were positioned in each vial. Both seeds in each vial were MR scanned simultaneously on days 11 and 26 after implantation. The data obtained from the known seed in each vial are used to calibrate the gel dose response which, for the prolonged irradiation duration necessitated by the investigated dose rates, depends on the overall irradiation time. Data for this study are presented according to the AAPM TG-43 dosimetric formalism. Polymer gel results concerning the new seed are compared to corresponding, published dosimetric results obtained, for the purpose of the new seed clinical implementation, by our group using the established methods of Monte Carlo (MC) simulation and thermo-luminescence dosimetry (TLD). Polymer gel dosimetry yields an average dose rate constant value of Λ = (0.921 ± 0.031) cGy h−1 U−1 relative to MCΛ = (0.929 ± 0.014) cGy h−1 U−1, TLDΛ = (0.951 ± 0.044) cGy h−1 U−1 and the average value of Λ = (0.940 ± 0.051) cGy h−1 U−1 proposed for the clinical implementation of the new seed. Results for radial dose function, gL(r), and anisotropy function, F(r, θ), also agree with corresponding MC calculations within experimental uncertainties which are smaller for the polymer gel method compared to TLD. It is concluded that the proposed polymer gel–magnetic resonance imaging methodology could be used at least as a supplement to the established techniques for the dosimetric characterization of new low energy and low dose rate interstitial brachytherapy seeds.