Polylactide-b-Poly(Ethylene Glycol)-b-Polylactide Triblock Copolymer Films for Using as Drug Delivery Carriers

Abstract

The objective of this work was to characterize the stereocomplex film properties prepared from different ratios of PLLA-PEG-PLLA/PDLA-PEG-PDLA. All ratios used were homogeneous in texture with a small size of pores which increased as the PDLA-PEG-PDLA ratio was increased. The PDLA-PEG-PDLA supported the increase of stereocomplexation of the film's texture. With tetracycline, the increasing of pores on the film surfaces were observed, but not interfered stereocomplexation of the films. However, the drug helped to enhance the homo-crystalline formation. The stereocomplex structure of films both with and without tetracycline have completely formed when the ratios of PLLA-PEG-PLLA/PDLA-PEG-PDLA used were 60/40 and 70/30, respectively. The rate of drug release trends to decrease when the ratio of PDLA-PEG-PDLA increased. This indicated that the different ratios of PLLA-PEG-PLLA/PDLA-PEG-PDLA might be affected by the properties of film as well as the drug release pattern. The obtained results might be applied for designing film for specific proposing, especially as a hydrophobic drug carrier for drug controlled-release.