Abstract
Poly I:C, the double-stranded complex of polyinosinic and polycytidylic acids, was tested for activity in mice against infections produced by Columbia SK virus and viruses of clinical importance. Poly I:C had high activity against the SK virus. It had marginal activity, and only when given intranasally, against strains of influenza virus belonging to types A, A1, A2 and B. It was active against infections produced by parainfluenza 1 virus, vaccinia virus, and herpes simplex virus. It was inactive against Coxsackie A21 and B1 virus.
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