Abstract
Due to the fact that all diseases began to be considered as multifactorial, the main direction of pharmacology in the 21st century is the design of multitarget ligands. The relevance of this approach is confirmed by the authors’ research in the field of analysis of the spectrum of affinity for nine ion channels of the heart for three antiarrhythmic drugs, as well as the results of initiatory research into the search for fundamentally new multifunctional multitarget inhibitors of glycation end-product receptors.
Highlights
Due to the fact that all diseases began to be considered as multifactorial, the main direction of pharmacology in the 21st century is the design of multitarget ligands
Было введено даже такое понятие, как «грязные лекарства», которые взаимодействуют с несколькими фармакологически релевантными биомишенями, в связи с чем проявляют несколько терапевтических эффектов и, как вероятное следствие, обладают значительным числом побочных эффектов [7]
Титаргетных ингибиторов рецепторов конечных продуктов гликирования, действующих одновременно как на AGE-рецепторы, так и на белки-мишени передачи сигнала от RAGE к NF-kB
Summary
Due to the fact that all diseases began to be considered as multifactorial, the main direction of pharmacology in the 21st century is the design of multitarget ligands. The relevance of this approach is confirmed by the authors’ research in the field of analysis of the spectrum of affinity for nine ion channels of the heart for three antiarrhythmic drugs, as well as the results of initiatory research into the search for fundamentally new multifunctional multitarget inhibitors of glycation end-product receptors. ПОЛИФУНКЦИОНАЛЬНЫЕ МУЛЬТИТАРГЕТНЫЕ ЛЕКАРСТВЕННЫЕ СРЕДСТВА КАК ОСНОВА ФАРМАКОЛОГИИ 21 ВЕКА Павел Михайлович Васильев Волгоградский государственный медицинский университет, г.
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