Abstract
We developed a high throughput analytical method using on-line solid phase extraction coupled with isotope dilution high-performance liquid chromatography–tandem mass spectrometry (on-line SPE–HPLC–MS/MS) to simultaneously determine the concentrations of 17 polyfluoroalkyl chemicals (PFCs) in house dust. The sample preparation includes dispersion of the dust samples in 0.1 M formic acid:MeOH (1:1), followed by agitation and filtration, addition of the isotope-labeled internal standard solution to the filtrate, and analysis by on-line SPE–HPLC–MS/MS. The limits of quantitation were <4.0 ng/g. The method accuracies ranged between 73.2% and 100.2% for the different analytes at two spike levels. We confirmed the validity of the method by analyzing 39 household dust samples collected in 2004. Of the 17 PFCs measured, 6 of them—perfluorobutane sulfonate (PFBuS), N-ethyl-perfluorooctane sulfonamide, 2-( N-ethyl-perfluorooctane sulfonamido) acetic acid (Et-PFOSA-AcOH), 2-( N-methyl-perfluorooctane sulfonamido) ethanol (Me-PFOSA-EtOH), perfluorohexane sulfonate (PFHxS), and perfluorooctane sulfonate (PFOS)—had detection frequencies >70%. We detected PFOS, PFBuS, and PFHxS at the highest median concentration, followed by Et-PFOSA-AcOH and Me-PFOSA-EtOH.
Published Version
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