Abstract
AbstractNew types of polyanhydrides with advantageous properties with respect to biomedical use were synthesized. The first are aliphatic‐aromatic homopolyanhydrides of the structure: ‐(OOC‐C6H4‐O(CH2)x‐ CO‐)n (=1−10). These polymers display a zero‐order hydrolytic degradation profile for two to ten weeks, the time period of degradation is a function of the length of the aliphatic chain. Stability studies under anhydrous conditions showed that these polymers underwent reversible self‐depolymerization in chloroform but were stable in solid state for over 6 months at 25°C.The second type of polymer, unsaturated polyanhydride of the structure: [‐(OOC‐CH=CH‐CO)x‐(OOC‐R‐CO)y‐]n, have the advantage of secondary polymerization of double bonds to create a crosslinked matrix. These polymers were prepared from the corresponding diacids polymerized by melt condensation or in solution. Molecular weights of up to 44 000 and 30 000 were achieved for polyanhydrides of p‐carboxyphenoxyalkanoic acid and fumaric acid, respectively.
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