Poly (yellow PX4R) carbon paste electrode sensor for paracetamol: A voltammetric study

Abstract

• A poly (yellow PX4R) MCPE was developed through electropolymerization. • The MCPE outperforms the BCPE in terms of performance. • The sensor enables rapid, accurate and reliable sensing of paracetamol. • Revealed good sensitivity and selectivity. • An excellent analytical performance of designed sensor. A simple, novel and less cost yellow (PX4R) modified carbon paste electrode (Po-YPX4R-MCPE) was successfully fabricated for the detection of paracetamol (PAR) in PBS (0.2 M, 7.4 pH). This reported senor showed excellent electrocatalytic activity, increased sensitivity, and fast electron transfer rate towards the oxidation of PAR in comparison to BCPE. The surface morphologies of BCPE and Po-YPX4R-MCPE were analyzed using scanning electron microscopy (SEM). The influence of pH, scan speed, and impact of concentration was studied at the sensor. The pH study reveals that the same amount of electrons and protons are involved in the redox reaction of PAR, and the scan speed study depicts that the electro-oxidation was adsorption controlled. In an optimal operating condition, Po-YPX4R-MCPE exhibits a fine linear increase for PAR oxidation in the concentration range of working dynamic range 10 to 60 µM with an estimated LOD of 0.084 µM. The DPV data indicate that there is a significant peak divergence of 0.097 V for PAR and 0.292 V for dopamine (DA) which could make it easier to determine them alone and simultaneously on the sensor. The established sensor also contributed to good stability and reproducibility. The described method has been employed for the determination of PAR in pharmaceutical tablets. Good recovery values indicate the efficacy and applicability of the sensor in detecting PAR.