Poly(thionine)-carbon nanotube modified carbon film electrodes and application to the simultaneous determination of acetaminophen and dipyrone

Abstract

Multi-walled carbon nanotube (MWCNT)-poly(thionine) (PTH) nanostructures were formed on carbon film electrodes (CFE), the polymer film being formed beneath or on top of MWCNT, to give two different sensor architectures, PTH/MWCNT/CFE or MWCNT/PTH/CFE. Characterization of the novel nanostructures was carried out by cyclic voltammetry, electrochemical impedance spectroscopy and scanning electron microscopy. The modified electrodes were then used for sensing acetaminophen (ACOP) and dipyrone by differential pulse voltammetry and fixed-potential amperometry independently and simultaneously. Analytical parameters were determined and the results compared with similarly modified electrodes reported in the literature. An interference study as well as recovery measurements in pharmaceutical samples was successfully performed.