Poly (Orange CD) sensor for paracetamol in presence of folic acid and dopamine

S D Sukanya,S A Hariprasad,S C Sharma,J K Shashikumara,B E Kumara Swamy

doi:10.1038/s41598-021-01311-5

S D Sukanya, S A Hariprasad + Show 3 more

Open Access

https://doi.org/10.1038/s41598-021-01311-5

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Journal: Scientific Reports	Publication Date: Nov 16, 2021
Citations: 5	License type: open-access

Affiliation: Jain University, Kuvempu University

Abstract

In the present work, Orange CD was chosen as an intriguing modifier for the electropolymerization on the surface of CPE by the CV technique. A novel, sensitive, and cost-effective poly (Orange CD) MCPE (PoOCD/MCPE) sensor was utilized for the selective detection of paracetamol (PA) in 0.2 M phosphate buffer solution (PBS) of pH 7.4. The oxidation peak current of PA was vastly enhanced at the sensor. The scan rate study is suggested that electro-oxidation of PA was adsorption-controlled. The pH study testifies the redox pathways transport with the same quantity of electrons and protons. The detection limit of PA is found to be 2.64 µM. DPV results show that substantial peak separation between PA, folic acid (FA), and dopamine (DA) could be facilitating their individual and simultaneous determination on the sensor. The decorated sensor demonstrates high sensitivity, stability, reproducibility, repeatability and has been successfully exploited for the detection of PA in a tablet with promising results.

Highlights

In the present work, Orange CD was chosen as an intriguing modifier for the electropolymerization on the surface of CPE by the CV technique
PA is degraded by glucuronidation and sulfation into inactive metabolites, which are excreted in the urine, with just 5% of PA remaining u naltered[6]
Dopamine (DA) is the neurotransmitter involved in the functioning of the central nervous system

Summary

Introduction

Orange CD was chosen as an intriguing modifier for the electropolymerization on the surface of CPE by the CV technique. A novel, sensitive, and cost-effective poly (Orange CD) MCPE (PoOCD/MCPE) sensor was utilized for the selective detection of paracetamol (PA) in 0.2 M phosphate buffer solution (PBS) of pH 7.4. Paracetamol (PA) is one of the most extensively used analgesics and antipyretic drugs in clinical practice[1,2] It is a very effective agent recommended for mild to moderate pain alleviation such as flu-induced fever, migraine, arthritis, and extenuates pain (headache, toothache, joint, muscular, chronic, postoperative)[3,4]. There are lots of methods like capillary electrophoresis11, titrimetry[12], SEC, LC–MS, HPLC13–15, chemiluminescence16, spectrofluorimetric[17], and spectrophotometry[18,19,20] which have been availed for the assessment of PA Among all these methods, the electrochemical method stands out with its simplicity, sensitivity, selectivity, modest and fast response. This work is intended to pave the way for the development of more efficient, dependable, and generally affordable sensors

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