Poly (L-leucine) modified carbon paste electrode as an electrochemical sensor for the detection of paracetamol in presence of folic acid

Abstract

Here, L-leucine based electrochemical sensor was designed for the simultaneous analysis of paracetamol (PA) and folic acid (FA). Electropolymerization of L-leucine was carried out on the surface of the carbon paste electrode (CPE). The electrochemical deeds of the biomolecules were explored through cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at the fabricated sensor. The invented poly (L-leucine) modified carbon paste electrode (PLCN-MCPE) showed very good interaction with the analyte molecules which results in the significant determination of PA and FA in terms of sensitivity and selectivity. The electrochemical reaction mechanism between the surface of the developed sensor and the analytes was carried out in terms of effects of scan rate, concentration, and the electrode process was found to be adsorption-controlled. The kinetics such as the number of electron transfer (n) and the heterogeneous rate constant (ko) were defined for PA and FA at MCPE. The lower limit of detection for PA and FA were assessed to be 0.44 and 2.4 µM correspondingly. As well, the availability of the sensor in real-world sample analysis was also investigated with satisfactory results.