Abstract
Fluorescent probes, based on doped polyaniline, poly(m-chloroaniline) and poly(1-naphthylamine) have been tailored for in vitro cell imaging application. Its structure was characterized by FTIR, UV–visible, fluorescence, atomic force microscopy and BET surface area analysis. The intensity of fluorescence in poly(m-chloroaniline) and poly(1-naphthylamine) was much stronger compared to polyaniline alone. The optimal emitting properties of poly(m-chloroaniline), poly(1-naphthylamine) and polyaniline were related to both structure and shape of the particle and behave according to concentration dependent manner. The poly(m-chloroaniline) and polyaniline emits greenish blue color while poly(1-naphthylamine) exibits intense red and greenish blue color emission respectively. Poly(m-chloroaniline) and poly(1-naphthylamine) demonstrate highly enhanced signals for fluorescence based cell imaging in K-562, U2-OS and MCF-7 cells. Above compounds are cytocompatible, and with no significant loss of viability in K-562, U2-OS and MCF-7 cells following treatment. Higher concentration of the material however, causes moderate loss in viability of the cell besides inducing cytotoxicity. Luminescent micro particles of doped poly(m-cholroaniline) and poly(1-naphthylamine) showed significant potential for biological and diagnostic application.
Published Version
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