Poly(Lactic Acid) Blends with Poly(Trimethylene Carbonate) as Biodegradable Medical Adhesive Material.

Shuang Zhang,Haiyun Chen,Minglong Yuan,Hongli Li,Mingwei Yuan

doi:10.3390/ijms18102041

Shuang Zhang, Haiyun Chen + Show 3 more

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https://doi.org/10.3390/ijms18102041

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Abstract

A novel medical adhesive was prepared by blending poly(lactic acid) (PLA) with poly(trimethylene carbonate) (PTMC) in ethyl acetate, and the two materials were proven to be biodegradable and biocompatible. The medical adhesive was characterized by 1H nuclear magnetic resonance (1HNMR), gel permeation chromatography (GPC), scanning electron microscopy (SEM) and differential scanning calorimetry (DSC). The water vapor transmission rate (WVTR) of this material was measured to be 7.13 g·cm−2·24 h−1. Its degree of comfortability was confirmed by the extensibility (E) and the permanent set (PS), which were approximately 7.83 N·cm−2 and 18.83%, respectively. In vivo tests regarding rabbit immunoglobulin M (IgM), rabbit immunoglobulin G (IgG), rabbit bone alkaline phosphatase (BALP), rabbit interleukin 6 (IL-6), rabbit interleukin 10 (IL-10), rabbit tumor necrosis factor α(TNFα), glutamic-oxaloacetic transaminase (AST/GOT), glutamic-pyruvic transaminase (ALT/GPT), alkaline phosphatase (AKP), blood urea nitrogen (BUN) and creatinine (Cr) indicated that the PLA-PTMC medical adhesive was not harmful to the liver and kidneys. Finally, pathological sections indicated that PLA-PTMC was more effective than the control group. These data suggest that in addition to having a positive effect on hemostasis and no sensibility to wounds, PLA-PTMC can efficiently prevent infections and has great potential as a medical adhesive.

Highlights

Each year, millions of people suffer from many types of wounds, including traumatic or surgical wounds, which require a proper closure
The results suggests that this type of biomaterial can efficiently reduce infections because it can form a thin and ventilated film quickly on the surface of the skin and promote wound repair, with less harm to other organs
An adhesive that reduces infections effectively because of its breathability was prepared from poly(lactic acid) (PLA) modified with poly(trimethylene carbonate) (PTMC) via blending at room temperature

Summary

Introduction

Millions of people suffer from many types of wounds, including traumatic or surgical wounds, which require a proper closure. Sutures can provide great tensile strength and show relatively low failure rates [8,9], the disadvantages of suturing are that it is time consuming, is not always technically possible, requiring anesthesia, and induces undesirable scar formation [9,10]. Staples damage surrounding tissues while evoking an inflammatory response and causing scar tissue formation. The limitations of currently-approved synthetic adhesives include poor adhesion in the presence of biological fluids, sensitization, an allergic response and inflammation. They can always cause problematic infections, which can cause many types of diseases. Development of new biomaterials with a low cost, low toxicity and less infection is quite essential

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