Abstract
Naked-eye detection of amino acids (AA) in water is of great significance in the field of bioanalytical applications. Herein, polymerized ionic liquids (PILs) with controlled chain length structures were synthesized via reversible addition–fragmentation chain-transfer (RAFT) polymerization and post-quaternization approach. The AA recognition performance of PILs with different alkyl chain lengths and molecular weights was evaluated by naked-eye color change and ultraviolet-visible (UV–vis) spectral studies. These PILs were successfully used for highly sensitive and selective detection of Arg, Lys, and His in water. The recognition performance was improved effectively with increased molecular weight of PILs. The biosensitivity of the PILs in water was strongly dependent on their aggregation effect and polarization effect. Highly sensitive and selective detection of AA was successfully accomplished by introducing positively charged pyridinium moieties and controlled RAFT radical polymerization.
Highlights
Amino acids (AA) play an important key role in many physiological processes (Mohr et al, 1998; Shahrokhian, 2010)
We introduce a kind of polymerized ionic liquids (PILs) with wellcontrolled architectures via reversible addition-fragmentation chain-transfer polymerization (RAFT polymerization) and postquaternization approach (Yuan et al, 2011; Mori et al, 2012)
The neutral polymers P4VPs with different molecular weights were obtained through reversible addition–fragmentation chain-transfer (RAFT) polymerization, azo-diisobutyronitrile (AIBN) as initiator agent, and cumyl dithiobenzoate (CDB) as RAFT chain transfer agent
Summary
Amino acids (AA) play an important key role in many physiological processes (Mohr et al, 1998; Shahrokhian, 2010). With increasing attention paid to human health, including diagnosis and treatment of diseases, scientists have devoted a lot of energy in exploring new methods for amino acid analysis (Vychytil et al, 2003; Zhou and Yoon, 2012). The prevalent problem is the solubility of AA in water and the occurrence of weak intermolecular interaction with recognition receptors in water (Riikka et al, 2014; Samantha and Francesca, 2014). It is urgently needed to develop new amino acid sensors that are highly sensitive and capable of molecular recognition in aqueous system that will aid in the enhancement of bioanalytical applications (Ooyama et al, 2013). In the process of amino acid detection, the calix[n]arenes have aroused many researchers’ concern and interest. The traditional sensors have some disadvantages requiring time-consuming design and
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