Abstract
A novel magnetic resonance imaging (MRI) diagnostic nanofibres were synthesised using Er2O3 nanoparticles (2% to 8%) embedded in the PEO matrix via electrospinning. The prepared PEO/Er2O3 nanofibres were fully characterised, and the magnetic relaxivity study for MRI contrast enhancement was evaluated. The findings showed that the fibre diameter became broader with increasing nanofiller loading. The encapsulation of Er2O3 nanoparticles in PEO fibres demonstrated excellent entrapment efficiency using the electrospinning method. The reduction of the crystallinity index provoked changes in the crystallite size, thus contributing to the amorphous component. The addition of Er2O3 nanoparticles in the PEO matrix demonstrated the changes in the conformational structure of the peak intensity, shape and position of the C–O–C stretching absorptions. PEO/Er2O3 nanofibres have successfully demonstrated potential T2 and T1-T2 dual-mode diagnostic nanofibres in MRI 1.5 T. Therefore, it is considered a great achievement in the detection sensitivity for cancer diagnosis due to its potential diagnostic use that can be activated in two-way.
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