Poly (d/l) lactide-polycaprolactone/bioactive glass nanocomposites: assessments of in vitro bioactivity and biodegradability

Javad Esmaeilzadeh,Saeed Hesaraki,Shokoufeh Borhan

doi:10.52547/jcc.3.4.1

Abstract

The in vitro assessments suggested the essential features for the bio screws applications. The effects of bioactive glass nanoparticles (BG) during in vitro studies of the poly (D/L) lactide (PDLLA)/polycaprolactone (PCL)/BG nanocomposites (PPB) were assessed. The PDLLA/PCL (PP) blends were chosen as control groups. Apatite formations capabilities, weight and pH variations, alkaline phosphatase activity (ALP), and MTT assay were assigned during different immersion times up to 6 months. The XRD and SEM results revealed the superior apatite formation of PPB in simulated body fluids (SBF) compared to PP. The weight loss and pH variation results illustrated the highest values related to PP. Moreover, the MG-63 cells cultures determined the better cell viability of the PPB compared to the PP blends. Although, there are no statistically significant differences between the two groups. In addition, similar trends are shown for the ALP results where these amounts after 2 and 3 weeks incubation are considerable for PPB in comparison to PP. However, there are also no statistically significant differences between the two groups. Overall, the in vitro bioactivity and biodegradability confirmed that the PPB implants can be promised as a proper candidate for anterior cruciate ligament reconstruction screws.

Highlights

Metallic screws are the most commonly used ligament graft fixation devices in anterior cruciate ligament reconstruction (ACLR)
It was reported that the mechanical properties of poly(d/l)lactide (PDLLA)/polycaprolactone (PCL) blends including tensile strength, tensile modulus, flexural strength, and flexural modulus [8] as well as creep and creep recovery [9] improved by adding the sol-gel derived bioactive glass nanoparticles (BGn) into the matrix
In PDLLA/PCL/BGn as nanocomposites (PPB) the distribution of BGn throughout the PDLLA/PCL matrix is appropriate which is evidenced by EDS line scan profiles (Not shown) [8]

Summary

Introduction

Metallic screws are the most commonly used ligament graft fixation devices in anterior cruciate ligament reconstruction (ACLR). The carcinogenic potential and the possibility of corrosion manner of metallic screws prompted the surgeon to recommend their removal during a second surgery To overcome such problems, polymeric screws especially biodegradable ones may be a superior alternative for metallic screws [4]. There are some concerns with the use of biodegradable screws including breakage during insertion and inflammatory reactions which may cause absorption of the adjacent tissues. They are not able to promote the bone ingrowths and subsequently leave voids in the tissue once the screws have been fully degraded [6]. Adjacent bones could interact with screws and attach to the bioactive fillers of bioscrews while the polymeric matrix is simultaneously degraded [11]

Methods

Results

Conclusion