Abstract
Current study aimed at enriching the poly(ε-caprolactone)/bioactive glass composite films with polyphenols extracted from sage. Bioactive glass particles were synthesized with the use of sol-gel and melt-quenching methods. In vitro release kinetics of polyphenols, antioxidant activity against the ABTS•+ and DPPH• radicals, antiproliferative activity against WM266-4 cancer cells, bioactivity and surface wettability were evaluated. Materials showed not only significantly improved hydrophilicity and excellent in vitro bioactivity, but also potential antioxidant and anticancer activities. Moreover, the latest properties and polyphenol release kinetics can be controlled by the use melt-derived or gel-derived bioactive glass particles.
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