POlmesartan medoxomil surface solid dispersion-based orodispersible tablets: formulation and in vitro characterization

Abstract

This work aims to improve the dissolution of the poorly water soluble drug olmesartan medoxomil by using the surface solid dispersion (SSD) technique. Insoluble carriers, namely Avicel PH102, Aerosil 200, silicified microcrystalline cellulose, Lycatab, Starlac, sodium starch glycolate (SSG), and Kyron T-314, were used at three different drug: carrier ratios (1:1,1:5, and 1:9 w/w) to prepare SSDs by solvent evaporation method. SSD18 consisting of drug:SSG at 1:9 ratio and SSD20 consisting of drug:Kyron T-314 at 1:5 ratio showed the highest enhancement in the dissolution rate and efficiency compared to the plain drug and the physical mixture. The selected dispersion was formulated into orodispersible tablets (ODTs) by using four different disintegrants. F3 DC ODT (consisting of SSD20 and 5 % crospovidone) and F6 DC ODT (consisting of SSD18 and no disintegrant) exhibited low in vitro disintegration time and high percentage of olmesartan medoxomil dissoluted within 10 min.