Development, evaluation and characterization of surface solid dispersion for solubility and dispersion enhancement of irbesartan

Abstract

AimThe present study is to prepare and assess Irbesartan loaded surface solid dispersions (SSD) for enhancing the solubility and bioavailability of poor soluble drug. MethodIrbesartan loaded SSD were prepared by co-evaporation method by using five different super disintegrants like crospovidone, croscarmellose sodium, potato starch, sodium starch glycolate and microcrystalline cellulose in three different drug–carrier ratios and evaluate for the in vitro drug release. ResultsThe prepared formulations were white in colour and free flowing. The spectral data reveals that there are no drug-polymer interactions. The P-XRD studies showed decrease in crystallinity of drug formulations when compared to the pure state of the drug. The SEM study was found to be irregular matrices due to the porous nature of the carrier with the fine particles of the drug embedded in it. The in vitro dissolution studies of surface solid dispersion of crospovidone with drug to carrier ratio of 1:10 showed highest dissolution rate with the dissolution efficiency of 98.18% (10 min) in comparison to the other formulations due to deposition of drug on the surface of an inert carrier leading to a reduction in the particle size of the drug, thereby providing a faster dissolution rate. ConclusionThe surface solid dispersion technique has been shown as a popular approach to improve the dissolution rate of poor soluble Irbesartan.