Abstract
Novel Pyridinones and pyrimidinones are synthesized by cyclic condensation of 2‐aminopyridines, respectively 2‐aminopyrimidines and corresponding acids. Condensation of 2‐amino‐4,6‐dimethylpyridine 1a and chloroacetic acid 2a gave corresponding imidazo‐[1,2,4]‐4,6‐dimethylpyridin‐3(2H)‐one 3a, whereas cyclocondensation of 1a and malonic acid 2b, gave 6,8‐dimethylpyrido‐[1,2‐a]‐pyrimidin‐2,4‐dione 3b. By condensation of 2‐amino‐4‐chloro‐6‐hydroxypyrimidine 1b and chloroacetic acid 2a, 7‐chloro‐5‐hydroxy‐2H‐imidazo‐[1,2‐a]‐pyrimidin‐3‐one 3c was synthesized, whereas cyclocondensatiuon of 1b and malonic acid 2b gave 8‐chloro‐6‐hydroxypyrimido‐[1,2‐a]‐pyrimidin‐2,4‐dione 3d. The antimicrobial activity of products 3(a‐d) were tested and results were submitted for their activities against E. coli, S. aureus and Candida albicans. Compounds 3c and 3a showed emphatic bactericide activity against E. coli. Considerable activity against S. aureus exhibited compounds 3b and 3c, whereas 3c and 3d exhibited the greatest activity against Candida albicans. In general there was observed that increasing of concentration causes greatest antimicrobial activity.
Published Version
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