Abstract
The electrochemical behaviour of the complex of Cu(II) with 4-chlorobenzylidene-4-aminoacetanilide (CAA) was studied. It was observed that CAA forms 1:1 complex with Cu(II) in between pH 6.5 to 7.1. It was found that the reduction process of Cu(II)- CAA complex is two electron reversible reduction process at D.M.E. The logarithm value of stability constant of Cu(II)-4-Chlorobenzylidene-4-aminoacetanilide (CAA) complex has been found to be 4.85.The redox properties of the complex was extensively investigated by electrochemical method using cyclic voltammetry (CV).The Cu(II) complexes exhibited quasi-reversible single electron transfer process.The Schiff base and its complex has been screened for theirin-vitroantibacterial (Escherichiacoli,Staphylococcus aureus,Vibrio choleraeandBacillus subtilis) and antifungal (Aspergillus nigerandPenicillium liliacinum) activities by minimum inhibitory concentration (MIC) method.
Highlights
The coordination chemistry of the metal complexes has been widely studied because of their interesting pharmacological properties the coordination chemistry of metal complexes of Schiff bases have been studied extensively[1,2,3,4,5] owing to their adequate flexibility and enough selectivity towards the central metal atom
The aim of present work is to synthesize and characterize Cu(II) metal complex with newly synthesized Schiff base derived from 4-Chlorobenzaldehyde and 4-aminoacetanilide (CAA), possessing donor sites of carbonyl oxygen and azomethine nitrogen
The Schiff base and its metal complexes were screened for their antimicrobial activity
Summary
The coordination chemistry of the metal complexes has been widely studied because of their interesting pharmacological properties the coordination chemistry of metal complexes of Schiff bases have been studied extensively[1,2,3,4,5] owing to their adequate flexibility and enough selectivity towards the central metal atom. The aim of present work is to synthesize and characterize Cu(II) metal complex with newly synthesized Schiff base derived from 4-Chlorobenzaldehyde and 4-aminoacetanilide (CAA), possessing donor sites of carbonyl oxygen and azomethine nitrogen. The Schiff base and its metal complexes were screened for their antimicrobial activity.
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