Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established treatment for patients with Parkinson’s disease (PD) with refractory motor symptoms. The success of this neuromodulation therapy is, however, highly related to stimulation being delivered to the proper location within the target region. STN can be functionally divided into sensorimotor, associative, and limbic sub-regions - each with different cortical connections. Stimulation of the dorso-lateral, or sensorimotor, STN ameliorates motor symptoms of PD, whereas stimulations of the limbic and associative sub-segments may induce affective and cognitive side-effects.
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