PO-02-196 INCIDENCE AND PREDICTORS OF NEW-ONSET ATRIAL FIBRILLATION IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY

Abstract

Development of AF in patients with hypertrophic cardiomyopathy is detrimental and increases the risk for heart failure and thromboembolic complications. Currently, limited information is available about the incidence and predictors of the development of de novo AF in this population. We aimed to evaluate the incidence and predictors of new-onset AF in patients with hypertrophic cardiomyopathy and no previous AF. Data were collected on all adult patients with hypertrophic cardiomyopathy with no prior clinical record of AF at the time of initial evaluation seen in our center between March 31, 2010, and May 21, 2021. A multivariate logistic regression model was used to obtain independent predictors of new onset of AF. Subsequently, a receiver operating characteristic curve was generated to evaluate the predictive power of the model. Of 360 hypertrophic cardiomyopathy patients with no previous history of AF, 84 (23%) had new onset of AF during an average follow-up of 3.7 years (6% per year). Patients who developed AF were 4 years older than patients who did not develop AF (58 vs. 54 yrs, P=.02). More males than females had new-onset AF (64% vs. 36%, P=.03). Older age, male sex, higher body mass index, higher left atrial volume index, absence of hypertension, and increased diastolic ventricular septal thickness were independent predictors of new-onset AF (Table). The receiver operating characteristic curve showed an area under the curve of 0.72 for this model (Figure). The incidence of new-onset AF in patients with hypertrophic cardiomyopathy is 6% per year. Older age, male sex, higher body mass index, higher left atrial volume index, absence of hypertension, and increased ventricular septal thickness are associated with increased risk of new-onset AF in this particular subset of patients.