Pneumokinetic therapy with glucocorticoids and 5 FU in the treatment of hypertrophic scars

Abstract

Corticosteroid injections, ointments, and patches are quite effective for hypertrophic scars. In addition to their direct anti-inflammatory effects, steroids also act by causing vasoconstriction. Current evidence suggests that 5‑FU is an alternative to glucocorticoids for the treatment of hypertrophic scars. According to research, 5‑FU can significantly improve the appearance of pathological scars and reduce the likelihood of relapse. Recently published studies have shown the effectiveness of laser therapies, including pulsed dye laser, fractional CO2‑laser, copper bromide laser, and UVA1 phototherapy. Purpose: to evaluate the effectiveness of pneumokinetic administration of drugs. Material and methods. The study group included 34 patients with hypertrophic scars who underwent 2 procedures of pneumokinetic therapy with glucocorticoids and 5‑FU, with an interval of 2 months. After another 1 month, laser therapy was performed with a neodymium laser (1064 nm). Efficiency control was carried out using DUB SkinScanner, a device for ultrasound examination and determination of morphofunctional parameters of the skin. Results. The study group showed pronounced positive dynamics. The thickness of the epidermis increased by 25.4 %; echodensity decreased by 17.8 %. The thickness of the dermis and its echodensity are more indicative; in relation to these parameters, the following dynamics were noted: a decrease in the thickness of the dermis by 48.0 % and an increase in echoicity by 46.6 %. Ultrasound data revealed a higher efficiency of the combined use of pneumokinetic therapy with glucocorticoids and 5‑FU with sequential laser therapy (neodymium laser at 1064 nm). Conclusion: The combined use of pneumokinetic therapy with glucocorticoids and 5‑FU with sequential laser therapy (neodymium laser at 1064 nm) is a highly effective method of treating hypertrophic scars and can be recommended for use in practical healthcare.