Pneumatically Driven Finger Movement: A Novel Passive Functional MR Imaging Technique for Presurgical Motor and Sensory Mapping

S Shriver,J.P O'Shea,G.H Glover,K.E Knierim,A.J Golby

doi:10.3174/ajnr.a2626

S Shriver, J.P O'Shea + Show 3 more

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https://doi.org/10.3174/ajnr.a2626

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Two of the most common reasons for failure to obtain adequate preoperative functional data are inadequate task performance and excessive head motion. With an MR imaging-compatible pneumatically driven manipulandum, passive motor tasks elicited reproducible contralateral activation in the M1 and S1 in 10 healthy controls and 6 patients. The SMA was localized in all healthy controls and in 5 of 6 patients. Head motion was reduced in passive tasks compared with active tasks.

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ABBREVIATIONS: ANOVA ϭ analysis of variance; fMRI ϭ functional MR imaging; BOLD ϭ blood oxygen levelϪdependent; M1 ϭ primary motor cortex; SMA ϭ supplementary motor area; S1 ϭ primary somatosensory cortex fMRI of the motor cortex has been shown to be useful in the presurgical evaluation of patients with brain tumors.[1]
Patients with lesions in and around the sensorimotor strip often have pre-existing weakness or sensory deficits that may hinder their performance during standard fMRI sensorimotor tasks such as finger tapping and hand clenching
We present a novel passive-movement task by using a custom-built manipulandum (Mag Design and Engineering, Redwood City, California), which reliably activates the S1, M1, and SMA and reduces overall head motion and task-correlated motion compared with voluntary active-movement paradigms in healthy controls and patients

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Patients with lesions in and around the sensorimotor strip often have pre-existing weakness or sensory deficits that may hinder their performance during standard fMRI sensorimotor tasks such as finger tapping and hand clenching. We present a novel passive-movement task by using a custom-built manipulandum (Mag Design and Engineering, Redwood City, California), which reliably activates the S1, M1, and SMA and reduces overall head motion and task-correlated motion compared with voluntary active-movement paradigms in healthy controls and patients.

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