PND26 Biological Activity of Ascaridole through Interference of Binding Sites of Topoisomerase I, Topoisomerase II, Acetylcholinesterase, SOD and Catalase for the Treatment of Alzheimer's Disorders

Abstract

Ascaridole was the best antihelmintics for the treatment of ascarids and hookworms for humans in the 1900’s. Ascaridole have been used in the traditional and modern medicine for the treatment of antihelmintics and other disorders. There are numerous disorders and anything that can cause oxidative stress in normal body cell to abnormality can generate Alzheimer's disease and inhibition of acetylcholinesterase (AChE) enzymes through drugs are the key factors for the treatment of Alzheimer's disease. Due to beneficial effect of ascaridole, present investigation deals the study related to basic application of ascaridole for their activity against Alzheimer's disorders through various model. Further to understand their beneficial effect on Alzheimer's in better way, molecular docking study have been performed to the binding sites of topoisomerase I, topoisomerase II, SOD, catalase and acetylcholinesterase enzymes know about their form of interactions and binding energy. All the presented data have been thoroughly analyzed and presented through different statistical methods. From the analysis of all the presented data, ascaridole revealed their effectiveness against oxidative stress disorders. Data analysis of literature work revealed their anti-oxidant potential in different cell line. Molecular docking study also suggests that ascaridole interfere binding sites of topoisomerase I, topoisomerase II, acetylcholinesterase, catalase and SOD. According to the results of the docking study, best fit to the binding pocket of acetylcholinesterase was shown by the ascaridole. Present work will be beneficial to the researcher in the field of medicine and other allied science for the development of medicine against Alzheimer's disorders disorders through ascaridole.