PMON246 Prevalence of Hypertension and Metabolic Syndrome in Women with PCOS from France and Brazil

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Abstract Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting women of reproductive age and has been associated with metabolic and reproductive abnormalities. Evidence from different geographic regions indicates that the metabolic features of PCOS may be influenced by ethnicity, lifestyle and sociocultural backgrounds. Also, metabolic disturbances seem to be found in higher frequency in referral than in unselected populations and from a clinical practice point of view, data from referral samples may be relevant for adjusting effective primary and secondary prevention strategies. Therefore, the aim of this study was to determine the prevalence of systemic arterial hypertension and metabolic syndrome (MBS) in women with PCOS from France and Brazil. We retrospectively assessed 314 French (FR) women and 236 Brazilian (BR) women with PCOS, according to the Rotterdam criteria, aging between 18 and 42 years and not using combined oral contraceptives or metformin. These women had been referred to the respective University Hospitals between 2014 to 2021 in France and 2014 to 2020 in Brazil. BR women had participated in previous studies conducted at our research center. Hypertension was defined according to the ACC/AHA 2017 and MBS according to the Joint Scientific Statement, 2009. Mean age was 26.0 (SD 5.9) years FR and 25.9 (SD 5.8) BR, p=0.87, and mean body mass index (BMI) was 27.1 (SD 6.8) FR and 31.3 (SD 7.5) BR P<0.001. The frequency of classical phenotype (A/B) was 83.7% in FR (n=262) and 77.1% in BR (n=182), p =0.071. Subsequent analyses were done including only women presenting the classical phenotype from each center. FR women with PCOS presented lower prevalence of overweight/obesity (53.7% FR vs. 84.6% BR, p<0.001), hypertension (32.6% FR vs. 71.6% BR, p<0.001) and MBS (12.5% FR vs. 38.5% BR, p< 0.001) than BR women with PCOS. Using logistic regression models for hypertension and MBS, it was found that both BMI and country contributed significantly for these prevalence results. In conclusion, women with PCOS living in France presented a less severe metabolic profile than those living in south Brazil. Differences in dietary pattern, lifestyle, socio-cultural features and ethnicity may have contributed to these results. Further studies are warranted to deeper characterize the influence of dietary composition and lifestyle on prevalence ratios of metabolic features in women living in France. Sources of Research Support: INCT-CNPq /FAPERGS Presentation: Monday, June 13, 2022 12:30 p.m. - 2:30 p.m.