Abstract
Bio-electrospraying and cell electrospinning is explored for reconstructing living biomaterials for regenerative biology and medicine. The investigations carried out in this study demonstrate these approaches as platform biotechnologies for tissue reconstruction for repair, replacement, and rejuvenation of damaged and/or ageing tissues and/or organs.
Highlights
The techniques of electrospraying and electrospinning have existed for at least a century.[1,2] Both these approaches employ a high voltage applied to a needle accommodating the flow of media, placed above a counter electrode which could either be grounded or have an opposite charge to the needle— introducing the charged media to an electric field
These endeavors have demonstrated the wider applicability of these technologies and in the last 20 years or so have been used for the direct handling of a wide range of materials, including bio-inspired materials.[4,5,6]
Despite the high voltages involved, these cells were surprisingly found to be viable post-electrospraying/electrospinning; this is due to both these techniques exploring high voltage DC supplies, while applying very low currents.[4,6]
Summary
The techniques of electrospraying and electrospinning have existed for at least a century.[1,2] Both these approaches employ a high voltage applied to a needle accommodating the flow of media, placed above a counter electrode which could either be grounded or have an opposite charge to the needle— introducing the charged media to an electric field. In agreement with our extensive previous studies,[10,11,12,13,14,15,16,17,18] no detrimental effects of bio-electrospraying or cell electrospinning were observed over a 72 h period, in comparison with cell culture controls (abbreviated to “CC”; Figure 1).
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