Abstract
Platelet-rich plasma (PRP) has been used clinically for its potentially enhanced soft-tissue healing properties. These healing properties, which stem from its derivation from autologous blood, have been attributed to the increased concentrations of growth factors and secretory proteins. PRP thereby hopefully enhances the recruitment, proliferation, and differentiation of cells involved in tissue regeneration1,2. The majority of orthopaedic applications for PRP can be classified into four groups: chronic tendinopathies, acute ligamentous injuries, muscle injuries, and intraoperative augmentation2. As noted by Hall et al.1, several PRP preparation systems are commercially available. The volume of autologous blood, centrifugation rate and time, delivery method, activating agent, leukocyte concentration, final PRP volume, and final platelet and growth factor concentrations vary among these systems. Hematologic variations between patients (e.g., leukocyte count and platelet count) may also affect the final PRP preparation. Debate continues regarding the optimal quantity of platelets and growth factors required for muscle and tendon-healing1. In this study, the authors …
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