Abstract
Plasma β-thromboglobulin (βTG) has been measured in 56 patients (mean age 63.6 years) with peripheral vascular disease (PVD) and 53 (Mean age 77.7) with recent and chronic cerebro-vascular disease (CVD). They were compared to 202 healthy subjects, 56 of whom were age and sex matched. In 33 of the PVD patients, platelet production time (PPT) heparin neutralising activity (HNA) and platelet aggregation (PA) induced by ADP, collagen epinephrine and thrombin were also measured. HNA was significantly shorter (p ≤ 0.0005) and plasma βTG higher (p ≤ 0.0005) in the PVD patients compared to the controls. The abnormal βTG was apparent (Wilcoxon test) only in 23 advanced PVD patients. In addition PPT was significantly shorter in 14 advanced PVD patients. The rate and extent of platelet aggregation in the PVD and plasma βTG in the CVD patients did not differ significantly from controls. There was no correlation between the four tests in the patients, suggesting that the tests were measuring various aspects of platelet function. These result indicate that in-vivo platelet consumption as well as platelet “release reaction” are enhanced in advanced PVD patients and may reflect a pre-thrombotic state.
Paper version not known (
Free)
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call