Platelet and leukocyte rich fibrin (L-PRF) applied in necrotizing Fasciitis treatment: case report

Abstract

The reconstruction of extensive defects on the face caused by infections is a challenge for the oral and maxillofacial surgeon. Platelet and leukocyte-rich fibrin (L-PRF) is an excellent option for rehabilitative treatment, as it contains molecular and cellular elements that induce repair, being a therapeutic biomaterial with high potential for soft tissue regeneration. This article presents the clinical case of the patient C.T.A.S., female, 21 years old, who reported multiple tooth extractions, with an evolution of 30 days of volume increase and intense algesia in the left bucal space. Diagnosing necrotizing fasciitis, the patient underwent IV antibiotic therapy and surgery to drain and debride the lesion. Postoperatively, therapy with platelet- and leukocyte-rich fibrin was initiated for tissue regeneration in the area affected by fasciitis. As an adjuvant to L-PRF membranes, low-level laser therapy and hyperbaric oxygenation sessions were performed. When using L-PRF to resolve this case, a satisfactory result was observed regarding the aesthetic-functional repair. In addition to having the advantage of being cost-effective, and having a simple protocol to be performed, L-PRF proved to be effective in promoting tissue regeneration.