Platelet activity in Chinese obese adolescents with and without insulin resistance

Abstract

To investigate the platelet activity in Chinese obese adolescents with and without insulin resistance. A cross-sectional study was performed in 159 obese Chinese adolescents to investigate their platelet activity using anthropometrics and biochemical parameters, oral glucose tolerance test and platelet testing. An index of insulin sensitivity, homeostasis model assessment of insulin resistance (HOMA-IR), and plasma fibrinogen, prothrombin fragment 1.2 (PT 1.2), fibrinopeptide A (FPA) and the levels of aggregation to collagen 1μg/ml, adenosine diphosphate (ADP) 10μmol/L and arachidonic acid (AA) 0.5mmol/L were measured. Obese adolescents with insulin resistance had significantly higher HOMA-IR, glucose response curve (AUC), insulin AUC, PT 1.2, FPA and fibrinogen and aggregation (to collagen 1μg/ml, ADP 10μmol/L and AA 0.5mmol/L) comparison with obese adolescents without insulin resistance (P<0.05). Moreover, a positive correlation was found between both aggregation (to collagen, ADP and AA) and HOMA-IR (ρ=0.716; P<0.01, ρ=0.682; P<0.01 and ρ=0.699; P<0.01, respectively), glucose AUC (ρ=0.479; P<0.01, ρ=0.416; P<0.01 and ρ=0.458; P<0.01, respectively) and insulin AUC (ρ=0.585; P<0.01, ρ=0.511; P<0.01 and ρ=0.576; P<0.01, respectively) in obese adolescents with insulin resistance. Insulin resistance is a major determinant of platelet activation in Chinese obese adolescents.