Abstract
The developmental growth of mesolimbic dopamine (DA) neurons and their reaction to partial deafferentation of the olfactory tubercle (OT) as reflected by changes in tyrosine hydroxylase (TH) activity and 3H-DA uptake were found to be very similar. A transient elevation of TH activity in A10 cell bodies preceded growth of axon terminals as reflected by a gradual but permanent increase in TH activity and 3H-DA uptake within the OT. Collateral sprouting, however, did not occur prior to an initial developmental period of the OT, the target area.
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